{"id":5801,"date":"2018-10-11T14:05:25","date_gmt":"2018-10-11T14:05:25","guid":{"rendered":"https:\/\/neuroscenter.com\/?p=5801"},"modified":"2023-01-06T16:27:20","modified_gmt":"2023-01-06T14:27:20","slug":"estres-memoria-e-hipocampo","status":"publish","type":"post","link":"https:\/\/neuroscenter.com\/ca\/blog\/estres-memoria-e-hipocampo\/","title":{"rendered":"Estr\u00e9s, Memoria e Hipocampo"},"content":{"rendered":"

Los efectos del estr\u00e9s a nivel neurobiol\u00f3gico.<\/h2>

Las hormonas del estr\u00e9s, los glucocorticoides, se unen a las prote\u00ednas del receptor intracelular y act\u00faan como factores de transcripci\u00f3n que afectan la actividad del gen.<\/u><\/u><\/p>

Estos efectos gen\u00f3micos ocurren durante horas e incluso d\u00edas produciendo cambios a largo plazo en la plasticidad sin\u00e1ptica y la transmisi\u00f3n neuronal.<\/u><\/u><\/p>

Adem\u00e1s de esta v\u00eda gen\u00f3mica cl\u00e1sica, hay evidencia de que las hormonas del estr\u00e9s pueden tener efectos inmediatos y no gen\u00f3micos en la funci\u00f3n cerebral.<\/u><\/u><\/p>

Utilizando im\u00e1genes de resonancia magn\u00e9tica funcional no invasiva se han realizado estudios en\u00a0\u00a0ratas despiertas y adrenalectomizadas que\u00a0 recibieron dosis intravenosas de corticosterona que simulan los niveles sangu\u00edneos de hormona logrados con un estr\u00e9s modesto e intenso , y se ha constatado que las\u00a0dosis de corticosterona que simula un alto estr\u00e9s provoca\u00a0un aumento significativo de la actividad funcional en el hipocampo, la corteza del cerebro anterior y el hipot\u00e1lamo lateral minutos despu\u00e9s de la administraci\u00f3n.<\/u><\/u><\/p>

En el estr\u00e9s cr\u00f3nico estudios han demostrado que en situaciones prolongadas, la elevaci\u00f3n de los corticoesteroides, que el mismo produce, puede causar da\u00f1os selectivos en las neuronas piramidales de la regi\u00f3n CA3 del hipocampo.<\/u><\/u><\/p>

En las situaciones m\u00e1s extremas, el estr\u00e9scr\u00f3nico resulta en p\u00e9rdida importante de neuronas de la regi\u00f3n CA3, como as\u00ed tambi\u00e9n de da\u00f1o neuronal, mediante atrofia dendr\u00edtica de las neuronas de la regi\u00f3n CA3, que puede ocurrir bajo severas condiciones.Esta atrofia dendr\u00edtica ha sido demostrada en situaciones de estr\u00e9s que perduran durante 21 d\u00edas.<\/u><\/u><\/p>

Las hormonas del estr\u00e9s pueden tener efectos no gen\u00f3micos en la actividad cerebral que afectan potencialmente la respuesta cognitiva y conductual inmediata a una experiencia altamente emocional.<\/u><\/u><\/p>

Mediante la determinaci\u00f3n del Biorritmo de Cortisol y la DHEA-Sulfato en saliva, podemos estudiar y tener una informaci\u00f3n clave sobre la fase biol\u00f3gica de la situaci\u00f3n de estr\u00e9s. Valoramos el resultado del paciente dentro de las diferentes fases de respuesta al estr\u00e9s, en funci\u00f3n de sus valores de DHEA-Sulfato y de Cortisol de las 12h y las 16h.<\/u><\/u><\/p>

<\/u>\u00a0<\/u><\/p>

Dr. Juan A Cruz Velarde –\u00a0<\/u><\/u>Neur\u00f3logo –\u00a0<\/u><\/u>Instituto de Neurobiologia Funcional\u00a0<\/u><\/u><\/p>

www.neuronae.net<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Los efectos del estr\u00e9s a nivel neurobiol\u00f3gico. Las hormonas del estr\u00e9s, los glucocorticoides, se unen a las prote\u00ednas del receptor intracelular y act\u00faan como factores de transcripci\u00f3n que afectan la … Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":12529,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_joinchat":[],"footnotes":""},"categories":[110],"tags":[],"class_list":["post-5801","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","masonry-post","generate-columns","tablet-grid-50","mobile-grid-100","grid-parent","grid-33"],"yoast_head":"\nDescubre los Efectos del Estr\u00e9s a Nivel Cerebral - Neurobiolog\u00eda<\/title>\n<meta name=\"description\" content=\"Te Explicamos como el Estr\u00e9s puede Afectar Potencialmente Nuestro Razonamiento y Conducta luego de una Experiencia Altamente Emocional.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/neuroscenter.com\/ca\/blog\/estres-memoria-e-hipocampo\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Descubre los Efectos del Estr\u00e9s a Nivel Cerebral - 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